A second paper confirms the mRNA shots cause recipients to make less effective antibodies to the coronavirus over time
No one knows yet what the long-term effects of this change may be, but - spoiler alert - they probably aren't good. Also: what did Pfizer know and when did the company know it?
People who have received the mRNA Covid jabs from Pfizer and Moderna have an increasingly unusual immune system response after the second shot, German researchers have found.
The new finding confirms and expands a report in December from other German researchers, who found a similar trend in people who had received a booster shot. It was published Thursday in the peer-reviewed journal Frontiers in Immunology.
Much work needs to be done to understand the impact of these findings. But they may help explain the apparently endless waves of Covid highly mRNA jabbed countries are facing, as well as the fact that mRNA boosters now appear to raise the risk of Covid infection.
Intriguingly, the new piece lists as its editor Shikha Shrivastava, a “senior scientist” at Pfizer - evidence that Pfizer has known of this potential issue for several months at a minimum. The researchers submitted the piece to Frontiers in Immunology in mid-August.
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The details of the Frontiers paper are complex, but the researchers found that people produce more of a type of antibodies that do not strongly attack the virus months after receiving their second mRNA jab.
Antibodies attach to “antigens” - bacterial or viral invaders like Sars-Cov-2 - preventing them from entering our cells and triggering our immune systems to attack them. The mRNA vaccines make our bodies produce the coronavirus spike protein, causing our immune systems to make antibodies to the spike.
But antibodies come in several different classes and subclasses.
The new paper found that months after the second mRNA dose, people began to produce more of an antibody subclass called IgG4. IgG4 is usually the least common of the subtypes. It does not trigger a strong immune response after it latches to the virus.
The change was particularly obvious in people who had not been infected before receiving the vaccine, the researchers found.
The change also appeared to be dose-related. It occurred more strongly in people who had received the Moderna jab, which contains more than three times the mRNA as the Pfizer shot. (The fact that the other group of researchers found the change accelerated after a third shot is also evidence of a dose-response relationship.)
Finally, the researchers did NOT find a similar “class switch” in people who received the AstraZeneca Covid shot, which also causes recipients to make the spike protein, but does not use mRNA to do so.
Taken together, those findings suggest strongly that the immune system change to produce this weaker antibody is a protective response to an abnormality caused by the mRNAs.
The long-term impact of the switch to IgG4 antibodies is unclear.
But nearly all the wealthy countries that heavily used the mRNA jabs continue to endure waves of Covid and significant numbers of deaths. The problem is worst in countries like Japan, which had few Covid cases before vaccination and thus little natural immunity.
As the Frontiers in Immunology researchers wrote:
Intriguingly, the mRNA vaccines, and in particular the mRNA-1273 vaccine, induced increasing long-term anti-S1 serum IgG4 levels in naïve individuals with hitherto unclear influences on the fight against the pathogen.
Yep, "hitherto unclear influences.”
Don’t worry, we’ll clear them up eventually.
Too bad we didn’t work on that before we stuck a billion-plus people with mRNA.